Anti-aging Effect of Sargassum patens Extract in UVA-irradiated Human Dermal Fibroblasts

Purpose: Ultraviolet (UV) irradiation causes extrinsic aging of human skin. It is believed that UV caused phenomena such as skin erythema, wrinkle formation, and elasticity reduction.Methods: The effect Sargassum patens extract on COL1A1 MMP1 production in normal dermal fibroblasts was investigated a potential cosmetic raw material.Results: In this study, I assessed how affected COL1A1/COL3A1/MMP1/SODs/Catalase mRNA expression protein Collagen, type MMP1. Quantitative real-time reverse transcription–polymerase chain reaction demonstrated the increased levels COL1A1/COL3A1/SOD2/CAT genes. Additionally, when compared to UVA-treated fibroblasts, collagen extract-treated conditions. Furthermore, secreted were reduced by treatment. According these findings, antiaging antioxidative effects fibroblasts.Conclusion: Therefore, identified extract, findings indicated could be pharmaceutical ingredient for antiaging. Based this, expected conduct additional research cellular mechanisms.